Nanoemulsions are dispersions of nanodroplets made by processes of flow-induced droplet rupturing. NPH's nanoemulsion technologies can be used to improve the texture and feel of emulsion products with minimal reformulation. In many cases, reduced oil and surfactant content can be achieved in oil-in-water emulsion formulations while controlling and maintaining a desired texture and feel.

The processing methods are scalable and can be used with foods, cosmetics, and pharmaceuticals. Combining two key aspects of NPH's technologies, polypeptide-coated nanodroplets offer unique possibilities for controlled drug delivery and targeting. In fact, it is possible to create water-in-oil-in-water double nanoemulsions, which both inner and outer droplets are stabilized using synthetic diblock co-polypeptides. The internal water compartment can be loaded with a water-soluble cargo, providing the potential for co-localized delivery of bioactives that are oil and water based using double nanoemulsions.

1. Hanson, J. A.; Chang, C. B.; Graves, S. M.; Li, Z. B.; Mason, T. G.; Deming, T. J., Nanoscale double emulsions stabilized by single-component block copolypeptides. Nature 2008, 455 (7209), 85-U54.

2. Graves, S. M.; Mason, T. G., Transmission of visible and ultraviolet light through charge-stabilized nanoemulsions. Journal of Physical Chemistry C 2008, 112 (33), 12669-12676.

3. Chang, C. B.; Knobler, C. M.; Gelbart, W. M.; Mason, T. G., Curvature dependence of viral protein structures on encapsidated nanoemulsion droplets. Acs Nano 2008, 2 (2), 281-286.

4. Wilking, J. N.; Mason, T. G., Irreversible shear-induced vitrification of droplets into elastic nanoemulsions by extreme rupturing. Physical Review E 2007, 75 (4).

5. Mason, T. G.; Wilking, J. N.; Meleson, K.; Chang, C. B.; Graves, S. M., Nanoemulsions: formation, structure, and physical properties (vol 19, pg 079001, 2007). Journal of Physics-Condensed Matter 2007, 19 (7).

6. Mason, T. G.; Wilking, J. N.; Meleson, K.; Chang, C. B.; Graves, S. M., Nanoemulsions: formation, structure, and physical properties. Journal of Physics-Condensed Matter 2006, 18 (41), R635-R666.

7. Mason, T. G.; Graves, S. M.; Wilking, J. N.; Lin, M. Y., Extreme emulsification: formation and structure of nanoemulsions. Condensed Matter Physics 2006, 9 (1), 193-199.

8. Mason, T. G.; Graves, S. M.; Wilking, J. N.; Lin, M. Y., Effective structure factor of osmotically deformed nanoemulsions. Journal of Physical Chemistry B 2006, 110 (44), 22097-22102.

9. Graves, S.; Meleson, K.; Wilking, J.; Lin, M. Y.; Mason, T. G., Structure of concentrated nanoemulsions. Journal of Chemical Physics 2005, 122 (13).

10. Meleson, K.; Graves, S.; Mason, T. G., Formation of concentrated nanoemulsions by extreme shear. Soft Materials 2004, 2 (2-3), 109-123.